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KMID : 0605720100160020111
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Journal of the Korean Society of Biological Therapies in Psychiatry
2010 Volume.16 No. 2 p.111 ~ p.121
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Relationship between Change in Frontal Lobe Perfusion on Brain SPECT and Executive Function Test in Patients with Traumatic Brain Injury
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Seo Sang-Min
Kang Do-Young
Lee Moon-Sook
Park Jae-Hong
Choe Byeong-Moo
Kim Seong-Hwan
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Abstract
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Objectives: The aim of this retrospective study was to correlate change in frontal lobe perfusion on brain single photon emission computed tomography(SPECT) with executive function in patients with traumatic brain injury(TBI).
Methods: Twenty-six TBI patients without structural abnormality on brain magnetic resonance imaging were scanned by SPECT. Seoul Neuropsychological Screening Battery, K-Wechsler adult intelligence scale, Kims frontal-executive neuropsychological test were conducted to evaluate executive function. A voxel-based analysis using statistical parametric mapping(SPM) was performed to correlate frontal lobe perfusion on SPECT with executive function.
Results:There were significant correlations(p＜0.05) between neuropsychological tests, including alternating hand movement, fist-edge-palm, performance IQ, Stroop test-color reading, word fluency and retrieval efficiency, and frontal hypoperfusion on SPECT. retrieval efficiency showed the strongest correlation coefficient.
Conclusion: These finding suggests that retrieval efficiency is associated with frontal hypoperfusion on SPECT.
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KEYWORD
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Traumatic brain injury, Single photon emission computed tomography, Executive function, Statistical parametric mapping
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